| Rotation | PICO/Mini-CAT | Question |
| Rotation 2 – Emergency Medicine | PICO 1 | In adults with uncomplicated skin abscess treated with incision and drainage, does adjunctive antibiotic therapy compared with incision and drainage alone improve cure rates and reduce recurrence? |
| Rotation 2 – Emergency Medicine | PICO 2 | In adults with elevated serum lactate but no confirmed infection, does early empiric antibiotic administration compared with observation or targeted therapy improve clinical outcomes? |
| Rotation 2 – Emergency Medicine | PICO 3 | In hemodynamically stable adults with recent onset atrial fibrillation, does early rhythm control compared with rate control alone improve symptom resolution? |
| Rotation 3 – Family Medicine | PICO 4 | In patients with Type 2 diabetes without established cardiovascular disease, does adding SGLT2 inhibitors or GLP-1 receptor agonists compared with standard therapy reduce future cardiovascular events? |
| Rotation 3 – Family Medicine | PICO 5 | In adults over age 45 undergoing colorectal cancer screening, does combining stool-based testing with colonoscopy compared with colonoscopy alone improve detection of colorectal cancer? |
| Rotation 3 – Family Medicine | PICO 6 | In adults above 65 years old, does getting the influenza vaccine compared to not getting the vaccine reduce the risk of contracting pneumonia during the cold season? |
| Rotation 4 – Internal Medicine | Mini-CAT | In adults with Hashimoto’s disease already treated with levothyroxine, does the addition of T3 (liothyronine) lead to reduced fatigue and improved quality of life compared to continuing levothyroxine monotherapy alone? |
| Rotation 5 – Psychiatry | PICO 7 | In elderly patients with Alzheimer’s dementia experiencing severe agitation, does the use of scheduled dextromethorphan-quinidine compared to low dose atypical antipsychotics reduce agitation and decrease frequency of adverse events, such as falls? |
| Rotation 5 – Psychiatry | PICO 8 | In young adults with generalized anxiety disorder, does guided internet delivered cognitive behavioral therapy compared with traditional in person cognitive behavioral therapy result in non-inferior reductions in anxiety symptoms as measured by GAD-7 scores and improved cost effectiveness? |
| Rotation 5 – Psychiatry | PICO 9 | In adults with mild to moderate major depressive disorder, does participation in a structured aerobic exercise program, compared with standard treatment alone, result in a greater reduction in depressive symptoms, improve overall functioning, and remission rates? |
| Rotation 6 – Pediatrics | Mini-CAT |
